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For over a decade, millions of people, in more than 60 countries around the world, have benefited from DONA™. DONA™ contains the ORIGINAL Glucosamine Sulfate that has been thoroughly studied and shown effective to promote cartilage metabolism, protect joint structure and support joint mobility. DONA™ once-a-day dosage offers the more convenient, easy to remember regimen for maintaining joint health.

DONA™ USA NEWS

64th American College of Rheumatology
and 35th Association of Rheumatology Health Professionals Annual Scientific Meetings

October 29 - November 2, 2000
Philadelphia, Pennsylvania

* The independent, confirmatory evidence of the long term disease-modifying effect by Glucosamine Sulfate (DONA™)

Glucosamine Sulfate decreases progression of knee osteoarthritis in a long-term,randomised, placebo-controlled,independent,confirmatory trial.
Karel Pavelka,et al.

* Follow-up studies to the former evidence of the disease-modifying effect by Glucosamine Sulfate (DONA™) Biochemical markers and Disease Modification

Cartilage degradation in knee osteoarthrithis patients with elevated levels of urinary collagen type II C-Telopeptide fragments.
Stephan Christgau,et al.

Changes in serum osteocalcin but not other serum and urinary markers of bone and cartilage metabolism,measured after 12 months,are significantly correlated to long-term (36 months) structural changes in knee osteoarthritis (OA)..
Jean-Yves Reginster,et al.

Biochemical markers of bone and cartilage remodeling are poorly correlated with clinical and radiological severity of knee osteoarthritis.
Jean-Yves Reginster,et al.

* Efficacy of Glucosamine Sulfate (DONA™) on symptoms of OA at different joint localizations.

Efficacy of Glucosamine Sulfate in osteoarthritis of the lumbar spine:a placebo-controlled, randomized,double-blind study.
Klaus K Foerster,et al.